Will it work on a clog?

If the material is biodegradable, yes. However, in most cases, the stoppage is not caused by a complete clog of something in the trap. Most likely, it is several feet of pipe that is filled with firm “sludge”, and it may take several days for the bacteria to eat through this long blockage. Therefore, it is suggested that a mechanical cable be used to restore the flow. Then begin BIO-CLEAN treatments to remove any remaining waste build-up. Regular maintenance treatments will prevent new build-up.